Human motion capture is frequently used to study rehabilitation and clinical problems, as well as to provide realistic animation for the entertainment industry. IMU-based systems, as well as Markerbased motion tracking systems, are most popular methods to track movement due to their low cost of implementation and lightweight. This paper proposes a quaternion-based Extended Kalman filter approach to recover the human leg segments motions with a set of IMU sensors data fused with cameramarker system data. In this paper, an Extended Kalman Filter approach is developed to fuse the data of two IMUs and one RGB camera for human leg motion tracking. Based on the complementary properties of the inertial sensors and camera-marker system, in the introduced new measurement model, the orientation data of the upper leg and the lower leg is updated through three measurement equations. The positioning of the human body is made possible by the tracked position of the pelvis joint by the camera marker system. A mathematical model has been utilized to estimate joints’ depth in 2D images. The efficiency of the proposed algorithm is evaluated by an optical motion tracker system.